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구인기관 정보
조회 386  스크랩 인쇄하기 주소복사 트위터 공유 페이스북 공유 
기관명 University of Texas Health San Antonio
홈페이지 https://physiology.uthscsa.edu
채용정보 웹페이지
https://physiology.uthscsa...
소속책임자 Jun Hee Kim
주소 국외
기관분류 대학(의과대학제외)
기관소개 The University of Texas Health Science Center at San Antonio(UTHSCSA) is an institute of health science education and research located in San Antonio, Texas. UTHSCSA is the largest health sciences university in South Texas. It is ranked as the 14th largest medical school in the United States in terms of enrollment.

The Department of Cellular and Integrative Physiology is a basic science department in the Long School of Medicine at the University of Texas Health San Antonio. The Department was founded in 1972 and is renowned for its seminal contributions in many scientific areas including cardiovascular physiology, neurophysiology and the physiological basis of aging. We use state of the art genetic and molecular methodologies in combination with optical tools to understand the mechanisms that underlie neural circuitry, tissue and cellular physiology in normal health; and how they go awry in injuries or diseases. Several cutting-edge research areas being actively pursued include ion channel physiology and modulation, neuromodulatory behavioral mechanisms, glial biology and role of glia in disease, traumatic brain injury, neurovascular mechanisms of cardiac function, cardioprotection pathways, renal salt homeostasis and age-related neurological pathologies.

Dr. Kim's research interest is to understand regulatory mechanisms of presynaptic excitability and synaptic transmission in the central nervous system (CNS) during physiological or pathological conditions, using electrophysiology and imaging techniques. The long-term research goal is to determine neurophysiological mechanisms underlying central auditory dysfunctions to improve preventive/ therapeutic strategies for auditory disorders caused by various neurodegenerative diseases or aging (e.g. Multiple Sclerosis, MS, Alzheimer’s disease, AD, or Traumatic brain injury, TBI).
인사담당자 정보
담당자이름 Jun Hee Kim
연락처 E-mail: kimjh(at).uthscsa.edu ,  전화: 1-210-562-4013
채용정보
모집분야 Biophysics,  Neuroscience,  Physiology
업무내용

A potential postdoc will perform patch-clamp recordings and live cell imaging in the acute brain slices.
Thus, candidates are 
1. Required an expert in electrophysiology in brain tissues.
2. Qualified with research articles related to brain function with patch-clamp recordings or/and imaging.

The goal of our research program is to understand the physiological mechanisms that regulate synaptic function and dysfunction in the auditory nervous system during development, maintenance and disease/injury. After beginning my career as an independent investigator at UTHSCSA in 2010, we have investigated synaptic function and dysfunction related the central myelination in the auditory nervous system, which was successfully funded by the NIH NIDCD (R03 and R01). My lab produced 9 research articles related to demyelination, axon terminal excitability, and synaptic transmission. In the parent R01, we focus on the role of myelination in maintaining synaptic function, and the mechanisms by which myelination supports auditory transmission. Briefly, the ongoing experiments associated with the parent award use a combination of in vivo auditory brainstem response test and patch clamp recordings of auditory neurons in brainstem slices to determine the role of myelination on the functional and structural maturation of synapses, and the mechanisms underlying auditory dysfunction in myelin-deficient auditory brainstem. Our long-term research goal is to determine neurophysiological mechanisms underlying central auditory dysfunctions to improve preventive/ therapeutic strategies for auditory disorders caused by various neurodegenerative diseases or aging (e.g. Multiple Sclerosis, MS, Alzheimer’s disease, AD, or Traumatic brain injury, TBI). Our published studies in the past funding period show that the loss of condensed myelination increases timing errors and failures in neurotransmission at the calyx of held synapses (Kim et al., 2013 a, b). Changes at the level of individual synapses and alteration in ion channel distribution at axonal domains are associated with delayed and degraded signal transmission along the auditory pathway in a central demyelinating model, Long Evans Shaker rat (Kim et al., 2013b, Berret et al., 2016, Xu et al., 2017). In addition to these findings, we have investigated  how neurons and oligodendrocytes (OLs) bi-directionally communicate with high temporal and spatial resolution. Our recent study demonstrates a novel excitable OL: A subpopulation of OLs that conducts functional Nav1.2 currents sufficient to evoke APs and the downregulation of spiking in these excitable OLs impairs myelination in the rat auditory brainstem (See the below). It is striking that a loss of spiking in this excitable subpopulation of OLs had a widespread impact on myelination, suggesting that this subpopulation plays an essential role in promoting myelination as a key coordinator. Our primary goal of this project is to investigate Nav1.2-expressing excitable OLs and their novel functions in activity-dependent myelination and social behaviors. Unveiling a novel mechanism of activity-dependent myelination is an essential step for understanding the underlying mechanisms of autism and developing efficient therapeutic strategies.
Berret E, Barron T, Xu J, Debner E, Kim EJ, and Kim JH (2017). Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation. Nature Communication 8, Article number: 557.
Our Based on these findings, we will expand our research field to hearing disorders in various neurodegenerative diseases, aging, or TBI. Ultimately, our goal is to identify novel and innovative therapies for interventions to prevent, manage, and treat auditory disorders caused by peripheral deficits.
채용조건
채용방식  계약직 채용형태  PostDoc
최종학력  박사 근무지  미국
급여조건  연봉 5300만원 이상 ~ 5700만원 미만 채용인원  2 명
복리후생  국민4대보험
전형방법 서류전형, 면접전형
제출서류 이력서, 자기소개서, 추천서, 논문/초록목록
기타안내
마감일자 2018년 11월 09일 부터 2018년 12월 31일 까지
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