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대메뉴안내: 농수식품
농림성과 수산성과 식품성과 인터뷰
사진없음
차예진(Ye Jin Cha)
선문대학교
조회178  주소복사  소셜네트워크로 공유하기
Protective effects of CpG-ODN 2007 administration against Edwardsiella tarda infection in olive flounder (Paralichthys olivaceus)

Ye Jin Cha, Chae Ryeong Lee, Joon Young Kwon, Yue Jai Kang*

Department of Aquatic Life and Medical Sciences, Sun Moon University, Asan-si, South Korea

* Corresponding author.

Abstract
In this study, we investigated the immunostimulatory and protective effects of CpG motif oligonucleotides (CpG-ODNs) against Edwardsiella tarda infection in olive flounder (Paralichthys olivaceus). Groups of fish injected with CpG-ODNs (1585, 1668, and 2007) or PBS (control) showed varying mortality rates in response to challenge with E. tarda. The survival rates of fish treated with CpG-ODN 1668 and 2007, which belonged to the same class type B, were 45% and 60%, respectively, with CpG-ODN 2007 showing the highest survival rate. Further analysis showed that the respiratory burst and bactericidal activities induced by CpG-ODN 2007 were higher than those in the control group (induced by non-CpG-ODNs) or in the group of fish induced by CpG-ODN 1585, which belonged to class type A. Additionally, the respiratory burst activity induced by CpG-ODN 2007 was higher than that induced by CpG-ODN 1668, despite similar bactericidal activity titers. In vivo experiments showed that CpG-ODN 2007 stimulation resulted in higher survival rates than CpG-ODN 1668 stimulation, possibly owing to differences in respiratory burst activity. In summary, we demonstrated that differences in CpG-motif or class type altered respiratory burst and bactericidal activities, resulting in differences in survival rates against E. tarda challenge in the olive flounder. Therefore, it is necessary to use CpG-ODNs optimized against E. tarda infection in olive flounder, because different CpG motifs belonging to the same class type have different effects.

Keywords : CpG-ODN class type, CpG-ODN 2007, Olive flounder (Paralichthys olivaceus), Immunostimulant, Edwardsiella tarda

논문정보
- 형식: Research article
- 게재일: 2017년 07월 (BRIC 등록일 2017-08-03)
- 연구진: 국내연구진 태극기
- 분야: Immunology, Marine_Biology, Veterinary_Science
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Google scholar (by Ye Jin Cha)
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사전접수: ~2017.10.13
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장소: 인천시 연수구 송도미래로 9 BRC 2동 2층 GE Healthcare APAC Fast Trak Center
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날짜: 2017.10.11
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