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대메뉴안내: 농수식품
농림성과 수산성과 식품성과 인터뷰
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엄민영(Min Young Um) 저자 이메일 보기
한국식품연구원
조회138  주소복사  소셜네트워크로 공유하기
A novel neurological function of rice bran: a standardized rice bran supplement promotes non-rapid eye movement sleep in mice through histamine H1 receptors

Min Young Um1,†, Sojin Kim2,†, Young-Ho Jin2, Minseok Yoon1, Hyejin Yang1, Jaekwang Lee1, Jonghoon Jung1, Yoshihiro Urade3, Zhi-Li Huang4, Sangoh Kwon5 and Suengmok Cho1,*

1
Division of Functional Food Research, Korea Food Research Institute, Seongnam, Republic of Korea
2 Department of Physiology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
3 International Institute for Integrative Sleep Medicine, University of Tsukuba, Japan
4 State Key Laboratory of Medical Neurobiology, Institute of Brain Sciences, Department of Pharmacology, Shanghai Medical College, Fudan University, Shanghai, China
5 S&D Research and Development Institute, Osong, Republic of Korea

These authors contributed equally to the present work.

*Correspondence : Suengmok Cho

Abstract
Scope : Although rice bran has been shown to be associated with a wide spectrum of health benefits, to date, there are no reports on its effects on sleep. We investigated the effect of rice bran on sleep and the mechanism underlying this effect.

Methods and results : Electroencephalography was used to evaluate the effects of standardized rice bran supplement (RBS) and doxepin hydrochloride (DH), a histamine H1 receptor (H1R) antagonist used as a positive control, on sleep in mice. The mechanism of RBS action was investigated using knockout (KO) mice and ex vivo electrophysiological recordings. Oral administration of RBS and DH significantly decreased sleep latency and increased the amount of non-rapid eye movement sleep (NREMS) in mice. Similar to DH, RBS fully inhibited H1R agonist-induced increase in action potential frequency in tuberomammillary nucleus neurons. In H1R KO mice, neither RBS nor DH administration led to the increase in NREMS and decrease in sleep latency observed in WT mice. These results indicate that the sleep-promoting effect of RBS is completely dependent on H1R antagonism.

Conclusions : RBS decreases sleep latency and promotes NREMS through the inhibition of H1R, suggesting that it could be a promising therapeutic agent for insomnia.

Keywords : Doxepin; Histamine H1 receptor; Hypnotic; Rice bran; Sleep

논문정보
- 형식: Research article
- 게재일: 2017년 07월 (BRIC 등록일 2017-07-25)
- 연구진: 국내(교신)+국외 연구진 태극기
- 분야: Food_Technology
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