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대메뉴안내: 농수식품
농림성과 수산성과 식품성과 인터뷰
A.M. Abd El-Aty
A.M. Abd El-Aty (A.M. Abd El-Aty) 저자 이메일 보기
건국대학교 수의과대학, Cairo University
 
조회 326  인쇄하기 주소복사 트위터 공유 페이스북 공유 
A quick and effective methodology for analyzing dinotefuran and its highly polar metabolites in plum using liquid chromatography-tandem mass spectrometry

Md. Musfiqur Rahmana, A.M. Abd El-Atyb, c,*, Md. Humayun Kabira, Hyung Suk Chunga, Han Sol Leea, Fazil Hacımüftüoğlud, Ji Hoon Jeonge, Byung-Joon Changf, Ho-Chul Shinc, Jae-Han Shima,*

a
Natural Products Chemistry Lab., College of Agriculture and Life Sciences, Chonnam National University, 300 Yongbong-dong, Buk-gu, Gwangju 500-757, Republic of Korea
b Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, 12211-Giza, Egypt
c Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea
d Department of Soil Sciences and Plant Nutrition, Faculty of Agriculture, Ataturk University, 25240 Erzurum, Turkey
e Department of Pharmacology, College of Medicine, Chung-Ang University, 221, Heuksuk-dong, Dongjak-gu, Seoul 156-756, Republic of Korea
f Department of Veterinary Anatomy, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea

*Corresponding authors at: Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Republic of Korea (A. M. Abd El-Aty) and Natural Products Chemistry Lab., College of Agriculture and Life Sciences, Chonnam National University, 300 Yongbong-dong, Buk-gu, Gwangju 500-757, Republic of Korea (J.-H. Shim).

Abstract
A simple and effective method was developed for analyzing dinotefuran and its three metabolites (MNG, UF, and DN) in plum using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Due to the polarity and high water miscibility, dinotefuran and some of its metabolites (especially DN) have some limitations to be extracted with acetonitrile and salt following the “QuEChERS” sample preparation methodology. Alternatively, the samples were extracted with methanol, and purified with dispersive-solid phase extraction procedure (d-SPE) using primary secondary amine (PSA) and C18 sorbents after filtration, and mass up. Due to the suppression effect originated from plum matrix, matrix-matched calibration curves, which provided good linearity with coefficient of determination (R2) ≥ 0.998, were used for quantification of all analytes. Blank plum samples fortified with 2 spiking levels (10 × LOQ and 50 × LOQ) yielded satisfactory recoveries for all tested analytes in the range of 83.01 to 110.18% with relative standard deviation (RSD) ≤ 8.91. The method was successfully applied to field-incurred plum samples and dinotefuran and all metabolites were positively detected and quantified. In conclusion, we suggest that the method can be expanded to polar compounds having solvent and partitioning problems in any of the versions of QuEChERS.

Keywords : Dinotefuran; Polar metabolites; Matrix effect; Plum; QuEChERS

논문정보
- 형식: Research article
- 게재일: 2017년 07월 (BRIC 등록일 2017-07-25)
- 연구진: 국내(교신)+국외 연구진 태극기
- 분야: Food_Technology
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