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대메뉴안내: 농수식품
농림성과 수산성과 식품성과 인터뷰
사진없음
Cong Thanh Hoang(Cong Thanh Hoang)
중앙대학교
조회300  주소복사  소셜네트워크로 공유하기
Molecular cloning of chicken interleukin-17B, which induces proinflammatory cytokines through activation of the NF-κB signaling pathway

Cong Thanh Hoang, Yeojin Hong, Anh Duc Truong, Janggeun Lee, Kyungbaek Lee, Yeong Ho Hong, PhD

Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea

Corresponding author : Yeong Ho Hong

Abstract
Interleukin (IL)-17B is a little known member of the IL-17 cytokine family, which plays an important role in immunity by regulating the expression of proinflammatory cytokines. In this study, we determined the coding sequence and biological functions of a novel chicken IL-17B (chIL-17B). The full-length chIL-17B coding sequence includes 567 nucleotides encoding 188 amino acids, which was identified in small intestinal epithelial cells. The chIL-17B protein shares 96.48% amino acid sequence identity with turkey, 92.57% with duck, and 44.92-64.06% with mammalian IL-17B proteins. ChIL-17B shares three exons and two introns with mammals, turkey, and duck. Moreover, IL-17B mRNA was more highly expressed than IL-17A mRNA in several organs of chickens infected with Salmonella and was upregulated in chicken cell lines following LPS stimulation. In addition, in chicken cell lines, chIL-17B induced the mRNA expression of several proinflammatory cytokines, including IL-1β, IL-6, LITAF, and INF-γ, but not IL-17A, and activated MyD88, TAK1, NF-κB1, and SOCS1, which are associated with the NF-κB signaling pathway. Taken together, chicken interleukin-17B plays a critical role in host defense against the bacterial pathogens, and regulates proinflammatory cytokines by activating the NF-κB signaling pathway.

Keywords : Chicken; IL-17B; NF-κB; Signal transduction; Cytokine

논문정보
- 형식: Research article
- 게재일: 2017년 04월 (BRIC 등록일 2017-04-18)
- 연구진: 국내연구진 태극기
- 분야: Immunology, Zoology
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Google scholar (by Cong Thanh Hoang)
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프리미엄 Bio일정 Bio일정 프리미엄 안내
오송신약개발지원센터 Platform Technology Boot Camp 2017(대전)
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사전접수: ~2017.08.24
날짜: 2017.08.25
장소: KAIST 의과학연구센터(E7) 1층 원격강의실
2017 한국분자세포생물학회(KSMCB) 정기학술대회
2017 한국분자세포생물학회(KSMCB) 정기학술대회
초록접수: ~2017.08.11
사전접수: ~2017.08.11
날짜: 2017.09.12~14
장소: COEX, Seoul, Korea
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