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농림성과 수산성과 식품성과 인터뷰
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Joseph Jeswin (Joseph Jeswin)
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조회 727  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Protective responses of two paralogs of granulocyte colony stimulating factor (GCSF) in rock bream, Oplegnathus fasciatus during bacterial and viral infection

Joseph Jeswin1, Ji-Min Jeong1, Jae-Dong Shim, Jin-Sol Bae, Chan-Il Park*

Department of Marine Biology & Aquaculture, College of Marine Science, Gyeongsang National University, 455, Tongyeong 650-160, Republic of Korea

1
These authors contributed equally to this work.

Corresponding author : Chan-Il Park

Abstract
Granulocyte colony stimulating factor (GCSF) has a key role in the production of neutrophilic granulocytes during normal hematopoietic development and release of neutrophils into the blood circulation. In this study we have identified and characterized two paralogs of GCSF (RbGCSF) in rock bream. Although RbGCSF-1 and RbGCSF-2 share low sequence conservation, its domains and protein structure still share significant similarity. Basal levels of RbGCSF-1 gene expression was high in peripheral blood leukocytes (PBLs), spleen and intestine whereas the RbGCSF-2 was highly expressed in PBLs and kidney, of healthy animals. A significant induction of RbGCSFs were observed after the challenge with Streptococcus iniae in kidney, spleen and gills during initial hours of infection. Whereas Edwarsiella tarda infection caused a reasonable expression in kidney. Red seabream iridovirus caused induction of RbGCSF-1 transcription only in gills during initial hours. This higher expression of RbGCSF in early hours may be its response to induce emergency hematopoiesis, due to shortage of neutrophils to combat the surge in pathogens. The difference in induction of RbGCSF paralogs during infection may constitute to its different roles or overlapping functions.

Keywords : Granulocyte colony stimulating factor; Rock bream; Red seabream iridovirus; Hematopoiesis; Cytokine

논문정보
- 형식: Research article
- 게재일: 2017년 04월 (BRIC 등록일 2017-04-13)
- 연구진: 국내연구진 태극기
- 분야: Immunology, Marine_Biology, Veterinary_Science
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프리미엄 Bio일정 Bio일정 프리미엄 안내
Molecular Mechanisms of Membrane Trafficking
Molecular Mechanisms of Membrane Trafficking
날짜: 2018.05.17~19
장소: 관악구 관악로 1 서울대학교 유전공학연구소 서관 1층 대강당
Yonsei Avison Biomedical Symposium 2018 - Organoid models of human disease
Yonsei Avison Biomedical Symposium 2018 - Organoid models of human disease
날짜: 2018.05.17~18
장소: 서대문구 신촌세브란스병원 은명대강당
임상시험 관리 과정
임상시험 관리 과정
날짜: 2018.04.18~20
장소: 경기도 성남시 분당구 판교역로 182 한국반도체산업협회건물 9층 강의장
삼성유전체연구소 국제심포지엄 Genomic Medicine 2018
삼성유전체연구소 국제심포지엄 Genomic Medicine 2018
사전접수: ~2018.05.25
날짜: 2018.05.25
장소: 강남구 일원동 삼성서울병원 본관 B1 대강당
국제세포사학회 2018 정기총회 및 학술대회
국제세포사학회 2018 정기총회 및 학술대회
초록접수: ~2018.05.01
사전접수: ~2018.05.10
날짜: 2018.05.31~06.02
장소: 서울대학교 문화관
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