[DEBUG-WINDOW 처리영역 보기]
BRIC을 시작페이지로 회원가입    로그인
BRIC농수식품
   
통합검색
BRIC 광고안내
오늘의 BRIC정보
모바일 BRIC RSS
트위터 페이스북
검색 뉴스레터 안내
좋은 연구문화 만들기
Bio일정
Bio일정
 
Bio일정 프리미엄(유료) 등록이란?
실험
실험
바이오 형광사진
실험의 달인들
Bio마켓
Bio마켓
BioJob
BioJob
Biojob 프리미엄(유료) 등록이란?
커뮤니티
커뮤니티
전체메뉴
대메뉴안내: 농수식품
농림성과 수산성과 식품성과 인터뷰
사진없음
Joseph Jeswin(Joseph Jeswin)
경상대학교
조회343  주소복사  소셜네트워크로 공유하기
Protective responses of two paralogs of granulocyte colony stimulating factor (GCSF) in rock bream, Oplegnathus fasciatus during bacterial and viral infection

Joseph Jeswin1, Ji-Min Jeong1, Jae-Dong Shim, Jin-Sol Bae, Chan-Il Park*

Department of Marine Biology & Aquaculture, College of Marine Science, Gyeongsang National University, 455, Tongyeong 650-160, Republic of Korea

1
These authors contributed equally to this work.

Corresponding author : Chan-Il Park

Abstract
Granulocyte colony stimulating factor (GCSF) has a key role in the production of neutrophilic granulocytes during normal hematopoietic development and release of neutrophils into the blood circulation. In this study we have identified and characterized two paralogs of GCSF (RbGCSF) in rock bream. Although RbGCSF-1 and RbGCSF-2 share low sequence conservation, its domains and protein structure still share significant similarity. Basal levels of RbGCSF-1 gene expression was high in peripheral blood leukocytes (PBLs), spleen and intestine whereas the RbGCSF-2 was highly expressed in PBLs and kidney, of healthy animals. A significant induction of RbGCSFs were observed after the challenge with Streptococcus iniae in kidney, spleen and gills during initial hours of infection. Whereas Edwarsiella tarda infection caused a reasonable expression in kidney. Red seabream iridovirus caused induction of RbGCSF-1 transcription only in gills during initial hours. This higher expression of RbGCSF in early hours may be its response to induce emergency hematopoiesis, due to shortage of neutrophils to combat the surge in pathogens. The difference in induction of RbGCSF paralogs during infection may constitute to its different roles or overlapping functions.

Keywords : Granulocyte colony stimulating factor; Rock bream; Red seabream iridovirus; Hematopoiesis; Cytokine

논문정보
- 형식: Research article
- 게재일: 2017년 04월 (BRIC 등록일 2017-04-13)
- 연구진: 국내연구진 태극기
- 분야: Immunology, Marine_Biology, Veterinary_Science
댓글등록
작성자
 
목록
마텍무역
마텍무역 스폰서배너광고 안내
외부관련링크
Google scholar (by Joseph Jeswin)
Pubmed (by Joseph Jeswin)
프리미엄 Bio일정 Bio일정 프리미엄 안내
오송신약개발지원센터 Platform Technology Boot Camp 2017(대전)
오송신약개발지원센터 Platform Technology Boot Camp 2017(대전)
사전접수: ~2017.08.24
날짜: 2017.08.25
장소: KAIST 의과학연구센터(E7) 1층 원격강의실
2017 한국분자세포생물학회(KSMCB) 정기학술대회
2017 한국분자세포생물학회(KSMCB) 정기학술대회
초록접수: ~2017.08.11
사전접수: ~2017.08.11
날짜: 2017.09.12~14
장소: COEX, Seoul, Korea
이전페이지로 돌아가기 맨위로 가기
 

BRIC 홈    BRIC 소개    회원    검색    문의/FAQ    광고    후원
Copyright © BRIC. All rights reserved. Contact member@ibric.org