Thi Thanh Hanh Nguyena, Jinbeom Sia, Choongil Kangb, Byoungsang Chungb, Donghwa Chunga, c, Doman Kima, c,*
a The Institute of Food Industrialization, Institutes of Green Bio Science & Technology, Seoul National University, Pyeongchang-gun, Gangwon-do 25354, South Korea
b OTTOGI Corporation, Anyang, Kyunggi 06177, South Korea
c Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang-gun, Gangwon-do 25354, South Korea
Curcuminoids from rhizomes of Curcuma longa possess various biological activities. However, low aqueous solubility and consequent poor bioavailability of curcuminoids are major limitations to their use. In this study, curcuminoids extracted from turmeric powder using stevioside (Ste), rebaudioside A (RebA), or steviol glucosides (SG) were solubilized in water. The optimum extraction condition by Ste, RebA, or SG resulted in 11.3, 9.7, or 6.7 mg/ml water soluble curcuminoids. Curcuminoids solubilized in water showed 80% stability at pH from 6.0 to 10.0 after 1 week of storage at 25 °C. The particle sizes of curcuminoids prepared with Ste, RebA, and SG were 110.8, 95.7, and 32.7 nm, respectively. The water soluble turmeric extracts prepared with Ste, RebA, and SG showed the 2,2-diphenyl-1-picrylhydrazyl radical scavenging (SC50) activities of 127.6, 105.4, and 109.8 μg/ml, and the inhibition activities (IC50) against NS2B-NS3pro from dengue virus type IV of 14.1, 24.0 and 15.3 μg/ml, respectively.
Keywords : Turmeric; Curcuminoids; Solubilization; Stevioside; Steviol glucoside; Rebaudioside A