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대메뉴안내: 농수식품
농림성과 수산성과 식품성과 인터뷰
Anh Duc Truong
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Chicken IL-26 regulates immune responses through the JAK/STAT and NF-κB signaling pathways

Anh Duc Truong, Yeojin Hong, Cong Thanh Hoang, Jangguen Lee, Yeong Ho Hong*

Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea

*Corresponding author.

Abstract
Chicken interleukin 26 (ChIL-26), a member of the IL-10 family, is expressed in T cells and can induce expression of proinflammatory cytokines. We examined the response of signal transduction pathways to ChIL-26 stimulation in the chicken T (CU91), macrophage (HD11), and fibroblast (OU2) cell lines. ChIL-26 activated JAK2 and TYK2 phosphorylation, as well as activation of STAT1, STAT3, and SHP2 via tyrosine/serine residues. We also showed that ChIL-26 activates the phosphorylation of NF-κB1, TAK1, and MyD88 kinase, which are key regulators of NF-κB signaling pathways. Moreover, ChIL-26 stimulation upregulated mRNA expression of chemokines (CCL4, CCL20, and CXCL14), Th1 (IFN-α, IFN-β, IFN-γ, IL-1β, and IL-6), Th2 (IL-4 and IL-10), and Th17 (IL12-p40, IL-17A, and IL-17F), and the Treg cytokines (TGF-β4); additionally, it increased Th1 and Th17 protein levels and nitric oxide production but did not affect cell proliferation. Together, these results suggest that ChIL-26-induced activation of chemokines, Th1, Th2, and, Th17, and the Treg cytokines is mediated through JAK/STAT and NF-κB signaling pathways in chicken T, macrophage, and fibroblast cell lines. These results indicate a key role for ChIL-26-induced polarization of the immune response and could reveal new therapeutic approaches for use in combination with molecules that activate T and macrophage cells via activation JAK/STAT and NF-κB signaling pathways.

Keywords : Chicken; JAK/STAT; NF-κB; Interleukin 26; Signaling pathways

논문정보
- 형식: Research article
- 게재일: 2017년 02월 (BRIC 등록일 2017-03-06)
- 연구진: 국내연구진 태극기
- 분야: Immunology, Zoology
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날짜: 2017.05.24~25
장소: 대전 유성구 가정로 141
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