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조회 697  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Adverse effects of BDE-47 on life cycle parameters, antioxidant system, and activation of MAPK signaling pathway in the rotifer Brachionus koreanus

Jun Chul Parka, 1, Jeonghoon Hana, 1, Min-Chul Leea, Hye-Min Kanga, Chang-Bum Jeonga, Dae-Sik Hwanga, Minghua Wangb, Jae-Seong Leea,*

a
Department of Biological Science, College of Science, Sungkyunkwan University, Suwon 16419, South Korea
b Center for Marine Environmental Chemistry and Toxicology, College of the Environment & Ecology, Xiamen University, Xiamen 361102, China

*Corresponding author.

1These authors contributed equally to this work.

Abstract
2,2’,4,4’-tetrabromodiphenyl ether (BDE-47) is widely dispersed endocrine disrupting chemicals (EDCs) in the aquatic ecosystem. Due to its devastating effect on marine organisms and insufficient database on toxicology, we investigated the adverse effects of BDE-47 on life parameters and antioxidant defense system following the reactive oxygen species (ROS) production in the monogonont rotifer Brachionus koreanus. In B. koreanus, the reduction in life cycle, fecundity, and population growth were observed in response to BDE-47. 50 μg/L BDE-47 significantly reduced (P<0.05) life expectancy and net reproductive rate. In response to 10 to 50 μg/L BDE-47 exposure, the oxidative stress was elicited via the generation of ROS, while the antioxidant related enzymes (e.g. glutathione S-transferase [GST] and glutathione reductase [GR]) have demonstrated significant activity levels (P < 0.05) to further alleviate the oxidative stress in a concentration dependent manner. Furthermore, transcript profiles of antioxidant function (GST-A, -O, and -S1-S8)-related genes have shown the significant increase over 24 h in response to BDE-47 (0, 10, 25, and 50 μg/L). As for MAPK signaling pathway analysis, up-regulation of their activities was observed at 25 μg/L BDE-47 but their activities have reduced at adult NOEC concentration of 50 μg/L. This study provides a better understanding of the effects of BDE-47 on life parameters, molecular defense system, and activation of MAPK signaling pathway against generated oxidants in the rotifer.

Keywords : Rotifer; Brachionus koreanus; BDE-47; Antioxidant system; Life parameters; MAPK signaling pathway

논문정보
- 형식: Research article
- 게재일: 2017년 02월 (BRIC 등록일 2017-03-02)
- 연구진: 국내(교신)+국외 연구진 태극기
- 분야: Marine_Biology
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프리미엄 Bio일정 Bio일정 프리미엄 안내
Molecular Mechanisms of Membrane Trafficking
Molecular Mechanisms of Membrane Trafficking
날짜: 2018.05.17~19
장소: 관악구 관악로 1 서울대학교 유전공학연구소 서관 1층 대강당
Yonsei Avison Biomedical Symposium 2018 - Organoid models of human disease
Yonsei Avison Biomedical Symposium 2018 - Organoid models of human disease
날짜: 2018.05.17~18
장소: 서대문구 신촌세브란스병원 은명대강당
삼성유전체연구소 국제심포지엄 Genomic Medicine 2018
삼성유전체연구소 국제심포지엄 Genomic Medicine 2018
사전접수: ~2018.05.25
날짜: 2018.05.25
장소: 강남구 일원동 삼성서울병원 본관 B1 대강당
국제세포사학회 2018 정기총회 및 학술대회
국제세포사학회 2018 정기총회 및 학술대회
초록접수: ~2018.05.01
사전접수: ~2018.05.10
날짜: 2018.05.31~06.02
장소: 서울대학교 문화관
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