[DEBUG-WINDOW 처리영역 보기]
즐겨찾기  |  뉴스레터  |  오늘의 정보 회원가입   로그인
BRIC홈 한국을 빛내는 사람들
버그알림
스폰서배너광고 안내  배너1 배너2 배너3
전체보기 추천논문 상위피인용 인터뷰 그이후 한빛사통계
서판길
서판길 (Pann-Ghill Suh) 저자 이메일 보기
UNIST
 
조회 965  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Forebrain-specific ablation of phospholipase Cγ1 causes manic-like behavior

Y R Yang1,2,13, J H Jung3,13, S-J Kim3, K Hamada4, A Suzuki4, H J Kim3, J H Lee3, O-B Kwon3, Y K Lee5, J Kim6, E-K Kim1, H-J Jang1, D-S Kang1, J-S Choi5, C J Lee6, J Marshall7, H-Y Koh6, C-J Kim8, H Seok9, S H Kim10, J H Choi1, Y-B Choi11, L Cocco12, S H Ryu3, J-H Kim3,* and P-G Suh1,*

1
School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea
2Aging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
3Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
4Division of Cancer Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
5Department of Psychology, Korea University, Seoul, Republic of Korea
6Center for Functional Connectomics, and Center for Neural Science, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea
7Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, USA
8Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea
9Department of Biomedical Engineering, Jungwon University, Goesan, Republic of Korea
10Department of Psychiatry, Dongguk University International Hospital, Goyang, Republic of Korea
11Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY, USA
12Cellular Signaling Laboratory, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy

*Correspondence: Professor J-H Kim, Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Life Sciences Building, Room 105, Cheongam-Ro 77, Nam-Gu, Pohang, Gyungbuk 37673, Republic of Korea; Professor P-G Suh, School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Building 104, Room 705, UNIST-gil 50, Eonyang-eup, Ulsan 44919, Republic of Korea.

13
The first two authors contributed equally to this work.

Abstract
Manic episodes are one of the major diagnostic symptoms in a spectrum of neuropsychiatric disorders that include schizophrenia, obsessive-compulsive disorder and bipolar disorder (BD). Despite a possible association between BD and the gene encoding phospholipase Cγ1 (PLCG1), its etiological basis remains unclear. Here, we report that mice lacking phospholipase Cγ1 (PLCγ1) in the forebrain (Plcg1f/f; CaMKII) exhibit hyperactivity, decreased anxiety-like behavior, reduced depressive-related behavior, hyperhedonia, hyperphagia, impaired learning and memory and exaggerated startle responses. Inhibitory transmission in hippocampal pyramidal neurons and striatal dopamine receptor D1-expressing neurons of Plcg1-deficient mice was significantly reduced. The decrease in inhibitory transmission is likely due to a reduced number of γ-aminobutyric acid (GABA)-ergic boutons, which may result from impaired localization and/or stabilization of postsynaptic CaMKII (Ca2+/calmodulin-dependent protein kinase II) at inhibitory synapses. Moreover, mutant mice display impaired brain-derived neurotrophic factor-tropomyosin receptor kinase B-dependent synaptic plasticity in the hippocampus, which could account for deficits of spatial memory. Lithium and valproate, the drugs presently used to treat mania associated with BD, rescued the hyperactive phenotypes of Plcg1f/f; CaMKII mice. These findings provide evidence that PLCγ1 is critical for synaptic function and plasticity and that the loss of PLCγ1 from the forebrain results in manic-like behavior.

논문정보
TOP5
2017년 선정
- 형식: Research article
- 게재일: 2017년 01월 (BRIC 등록일 2017-02-06)
- 연구진: 국내(교신)+국외 연구진태극기
- 분야: Molecular_Biology, Biochemistry, Neuroscience
관련 보도자료
조울증 일으키는 핵심 단백질의 작용 메커니즘 규명
미래창조과학부는 “기분이 들뜨고 가라앉는 증세가 반복적으로 나타나는 조울증의 원인 유전자를 발견하였으며, 조울증이 생기는 메커니즘을 규명했다”고 밝혔다. 뇌의 신호전달 단백질인 피엘씨감마원(PLCγ1)의 기능 이상이 조울증 발생의 핵심...
  댓글 0
등록
 
목록
에펜도르프코리아
관련링크
서판길 님 전체논문보기 >
관련인물
Jitendra N. Tiwari (UNIST)
김광수 (POSTECH)
김정국 (UNIST)
김정훈 (POSTECH)
문효열 (POSTECH, 울산과학기술대학...)
서영교 (UNIST)
양용렬 (UNIST, KRIBB)
오용석 (Rockefeller University)
정정훈 (POSTECH)
최장현 (Harvard Medical School)
관련분야 논문보기
Molecular_Biology

Biochemistry

Biochemistry

외부링크
Google (by Pann-Ghill Suh)
Pubmed (by Pann-Ghill Suh)
프리미엄 Bio일정 Bio일정 프리미엄 안내
2018 Ajou Biomedical International Symposium / Genoproteomic Signature of Human Diseases
2018 Ajou Biomedical International Symposium / Genoproteomic Signature of Human Diseases
날짜: 2018.11.26
장소: 아주대학교의료원 별관 대강당 (수원)
Human Genome Meeting 2019
Human Genome Meeting 2019
초록접수: ~2018.12.31
사전접수: ~2018.12.31
날짜: 2019.04.24~26
장소: 이화여자대학교 삼성홀
International Forum on Medical Innovation of Cell & Bio Therapy
International Forum on Medical Innovation of Cell & Bio Therapy
사전접수: ~2018.11.21
날짜: 2018.11.23
장소: 서울대학교병원 의생명연구원 1층 강당(대학로 소재)
위로가기
한빛사 홈  |  한빛사FAQ  |  한빛사 문의 및 제안
 |  BRIC소개  |  이용안내  |  이용약관  |  개인정보처리방침  |  이메일무단수집거부
Copyright © BRIC. All rights reserved.  |  문의 member@ibric.org
트위터 트위터    페이스북 페이스북    RSS서비스 RSS