[DEBUG-WINDOW 처리영역 보기]
BRIC을 시작페이지로 회원가입    로그인
BRIC한국을 빛내는 사람들
   
통합검색
배너1 배너2 스폰서배너광고 안내
오늘의 BRIC정보
모바일 BRIC RSS
트위터 페이스북
검색 뉴스레터 안내
좋은 연구문화 만들기
Bio일정
Bio일정
 
Bio일정 프리미엄(유료) 등록이란?
실험
실험
바이오 형광사진
실험의 달인들
소주에 고춧가루 태워 마시면 되는데..? 한국고추의 유래
Bio마켓
Bio마켓
BioJob
BioJob
Biojob 프리미엄(유료) 등록이란?
커뮤니티
커뮤니티
소주에 고춧가루 태워 마시면 되는데..? 한국고추의 유래
대중에게 유전체학에 대한 올바른 이해가 필요할까요?
전체메뉴
대메뉴안내: 한빛사
한빛사논문 추천논문 상위피인용논문 한빛사인터뷰 한빛사그이후 한빛사통계
마지현
마지현 (Ji-Hyun Ma) 저자 이메일 보기
연세대학교 의과대학
 
조회 1526  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Magnetic Force Nanoprobe for Direct Observation of Audio Frequency Tonotopy of Hair Cells

Ji-wook Kim†‡§, Jae-Hyun Lee†‡§, Ji-Hyun Ma∥#, Eunna Chung†‡§, Hongsuh Choi†‡§, Jinwoong Bok∥⊥#, and Jinwoo Cheon*†‡§

Center for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, Republic of Korea
Yonsei-IBS Institute, Yonsei University, Seoul 03722, Republic of Korea
§ Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea
Department of Anatomy, ⊥Department of Otorhinolaryngology, and #BK21 PLUS project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea

*Corresponding Author

Author Contributions
J.-w.K., J.-H.L., and J.-H.M. contributed equally to this work.

Abstract
Sound perception via mechano-sensation is a remarkably sensitive and fast transmission process, converting sound as a mechanical input to neural signals in a living organism. Although knowledge of auditory hair cell functions has advanced over the past decades, challenges remain in understanding their biomechanics, partly because of their biophysical complexity and the lack of appropriate probing tools. Most current studies of hair cells have been conducted in a relatively low-frequency range (<1000 Hz); therefore, fast kinetic study of hair cells has been difficult, even though mammalians have sound perception of 20 kHz or higher. Here, we demonstrate that the magnetic force nanoprobe (MFN) has superb spatiotemporal capabilities to mechanically stimulate spatially-targeted individual hair cells with a temporal resolution of up to 9 μs, which is equivalent to approximately 50 kHz; therefore, it is possible to investigate avian hair cell biomechanics at different tonotopic regions of the cochlea covering a full hearing frequency range of 50 to 5000 Hz. We found that the variation of the stimulation frequency and amplitude of hair bundles creates distinct mechanical responsive features along the tonotopic axis, where the kinetics of the hair bundle recovery motion exhibits unique frequency-dependent characteristics: basal, middle, and apical hair bundles can effectively respond at their respective ranges of frequency. We revealed that such recovery kinetics possesses two different time constants that are closely related to the passive and active motilities of hair cells. The use of MFN is critical for the kinetics study of free-standing hair cells in a spatiotemporally distinct tonotopic organization.

Keywords:  Magnetic nanoparticle; mechanical force; audio frequency; avian hair cell; tonotopy; bundle recovery time constant

논문정보
- 형식: Research article
- 게재일: 2016년 05월 (BRIC 등록일 2016-05-25)
- 연구진: 국내연구진태극기
  댓글 0
등록
 
목록
영화과학
관련링크
마지현 님 전체논문보기 >
관련인물
김지욱 (연세대학교, 기초과학연구...)
복진웅 (연세대학교 의과대학)
손은진 (연세대학교 의과대학)
이재현 (연세대학교)
천진우 (연세대학교)
외부링크
Google (by Ji-Hyun Ma)
Pubmed (by Ji-Hyun Ma)
프리미엄 Bio일정 Bio일정 프리미엄 안내
Molecular Mechanisms of Membrane Trafficking
Molecular Mechanisms of Membrane Trafficking
날짜: 2018.05.17~19
장소: 관악구 관악로 1 서울대학교 유전공학연구소 서관 1층 대강당
Yonsei Avison Biomedical Symposium 2018 - Organoid models of human disease
Yonsei Avison Biomedical Symposium 2018 - Organoid models of human disease
날짜: 2018.05.17~18
장소: 서대문구 신촌세브란스병원 은명대강당
삼성유전체연구소 국제심포지엄 Genomic Medicine 2018
삼성유전체연구소 국제심포지엄 Genomic Medicine 2018
사전접수: ~2018.05.25
날짜: 2018.05.25
장소: 강남구 일원동 삼성서울병원 본관 B1 대강당
국제세포사학회 2018 정기총회 및 학술대회
국제세포사학회 2018 정기총회 및 학술대회
초록접수: ~2018.05.01
사전접수: ~2018.05.10
날짜: 2018.05.31~06.02
장소: 서울대학교 문화관
이전페이지로 돌아가기 맨위로 가기
 

BRIC 홈    BRIC 소개    회원    검색    문의/FAQ    광고    후원
Copyright © BRIC. All rights reserved. Contact member@ibric.org

 
에펜도르프코리아