Young-Ki Paik1, Seul-Ki Jeong1, Gilbert S Omenn2,3, Mathias Uhlen4, Samir Hanash5, Sang Yun Cho1,13, Hyoung-Joo Lee1, Keun Na1, Eun-Young Choi1, Fangfei Yan6, Fan Zhang6, Yue Zhang6, Michael Snyder7, Yong Cheng7, Rui Chen7, Gyorgy Marko-Varga8, Eric W Deutsch3, Hoguen Kim9, Ja-Young Kwon9, Ruedi Aebersold10, Amos Bairoch11, Allen D Taylor4, Kwang Youl Kim1, Eun-Young Lee1, Denis Hochstrasser11, Pierre Legrain12 & William S. Hancock1,5
1Yonsei Proteome Research Center, Yonsei University, Seoul, Korea. 2Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. 3Institute for Systems Biology, Seattle, Washington, USA. 4Royal Institute of Technology, Stockholm, Sweden. 5Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 6Northeastern University, Boston, Massachusetts, USA. 7Stanford University, Palo Alto, California, USA. 8Lund University, Lund, Sweden. 9Yonsei University College of Medicine, Seoul, Korea. 10Department of Biology, Institute of Molecular Systems Biology, Eidgenossische Technische Hochschule, Zurich, Switzerland, and Faculty of Science, University of Zurich, Zurich, Switzerland. 11Swiss Institute of Bioinformatics and University of Geneva, Geneva, Switzerland. 12Ecole Polytechnique, Palaiseau, France. 13Present address: Korean National Institute of Health, Osong, Korea.
Correspondence to: Young-Ki Paik orWilliam S. Hancock
The Chromosome-Centric Human Proteome Project (C-HPP) aims to define the full set of proteins encoded in each chromosome through development of a standardized approach for analyzing the massive proteomic data sets currently being generated from dedicated efforts of national and international teams. The initial goal of the C-HPP is to identify at least one representative protein encoded by each of the approximately 20,300 human genes1, 2. The proteins will be characterized for tissue localization and major isoforms, including post-translational modifications (PTMs), using quantitative mass spectrometry and antibody reagents. Our rationale is that effective integration of proteomics data into a genomic framework will lead to improved knowledge of complex biological systems and facilitate access to protein level data. Although the intent to engage in a C-HPP program has been noted1, 2, 3, our objective here is to define the goals and process for its development as a multinational program.