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조박 (Park F. Cho) 저자 이메일 보기
McGill University
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조회 5749  인쇄하기 주소복사 트위터 공유 페이스북 공유 
A New Paradigm for Translational Control: Inhibition via 5''-3'' mRNA Tethering by Bicoid and the eIF4E Cognate 4EHP
Park F. Cho,1 Francis Poulin,1,4,* Yoon Andrew Cho-Park,1,3 Ian B. Cho-Park, 1,3 Jarred D. Chicoine, 2 Paul Lasko, 2 and Nahum Sonenberg 1,*

1 Department of Biochemistry, McGill Cancer Center, McGill University, 3655 Promenade Sir William Osler, Montréal, Québec H3G 1Y6, Canada
2 Department of Biology, McGill University, 1205 Avenue Dr. Penfield, Montréal, Québec H3A 1B1, Canada

Correspondence:
Francis Poulin
Phone: (510) 643-6227; Fax: (510) 643-5022 [F.P.]

Correspondence:
Nahum Sonenberg
Phone: (514) 398-7274; Fax: (514) 398-1287 [N.S.]

Translational control is a key genetic regulatory mechanism implicated in regulation of cell and organismal growth and early embryonic development. Initiation at the mRNA 5'' cap structure recognition step is frequently targeted by translational control mechanisms. In the Drosophila embryo, cap-dependent translation of the uniformly distributed caudal (cad) mRNA is inhibited in the anterior by Bicoid (Bcd) to create an asymmetric distribution of Cad protein. Here, we show that d4EHP, an eIF4E-related cap binding protein, specifically interacts with Bcd to suppress cad translation. Translational inhibition depends on the Bcd binding region (BBR) present in the cad 3'' untranslated region. Thus, simultaneous interactions of d4EHP with the cap structure and of Bcd with BBR renders cad mRNA translationally inactive. This example of cap-dependent translational control that is not mediated by canonical eIF4E defines a new paradigm for translational inhibition involving tethering of the mRNA 5'' and 3'' ends.

Footnotes

3 These authors contributed equally to this work.

4 Present address: Department of Integrative Biology, University of California, Berkeley, Berkeley, California 94720.

논문정보
- 형식: Research article
- 게재일: 2005년 05월 (BRIC 등록일 2005-05-09)
- 연구진: 국외연구진
- 분야: 생물학관련 모든분야
관련 인터뷰
1. 논문관련 분야의 소개, 동향, 전망을 간단히 설명 Since joining the laboratory of Dr. Nahum Sonenberg, at McGill University, in 2001 as a Graduate student, I strived to understand how translation (protein synthesis) is controlled in eukaryotes. Because all cellular function requires protein activity, any mechanistic insight into how proteins are synthesized will have profound consequences in our understanding of the biology of cell. Translation rates are often controlled at the initiation phase, a...
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