[DEBUG-WINDOW 처리영역 보기]
BRIC을 시작페이지로 회원가입    로그인
BRICBioJob
   
통합검색
배너1 배너2 배너3 스폰서배너광고 안내
오늘의 BRIC정보
모바일 BRIC RSS
트위터 페이스북
검색 뉴스레터 안내
좋은 연구문화 만들기
Bio일정
Bio일정
 
Bio일정 프리미엄(유료) 등록이란?
2017년 10월달 Bio일정을 확인하세요.
실험
실험
바이오 형광사진
실험의 달인들
Bio마켓
Bio마켓
BioJob
BioJob
Biojob 프리미엄(유료) 등록이란?
커뮤니티
커뮤니티
전체메뉴
대메뉴안내: BioJob
채용정보 대학원생모집 교수임용 구직정보 Job공감 Biolab
목록 조회499  인쇄  주소복사  소셜네트워크로 공유하기
BioWave  Vol. 19 No. 8 등록 2017.08.08 
경북대학교 동물바이러스학 연구실 이창희 교수
연구실 홈페이지
실험실 소개  
What we are working on
Nidovirus especially focusing on the important viruses in veterinary area as not only devastating viral pathogen threatening the global swine industry but also the veterinary virus model applicable to the study of human viruses
1. Porcine arterivirus (porcine reproductive and respiratory syndrome virus; PRRSV)
2. Porcine coronavirus (porcine epidemic diarrhea virus; PEDV)

Lab_intro1

What we are aiming to
Our research interest mainly focuses on fundamental understanding of virus and host interactions to decipher the molecular pathogenesis of porcine nidovirus

The final goals of our research are
1. To determine how viral and cellular components contribute to viral evasion of host defense mechanisms resulting in successful virus infection and spread using the porcine nidovirus model
2. To provide answers that improve our understanding of porcine nidoviruses in efforts to prevent and eliminate their-associated infectious diseases

Lab_intro1

연구내용  
1. To establish and apply reverse genetics system to study molecular virology

2. To study the structure-function relationship of the individual viral structural proteins during virus replication

3. To investigate the potential role of each non-structural protein for virus replication in the host
-Auxiliary functions regarding induction of cytopathology or intervention of innate immune responses in order to facilitate successful spread of virus infection

4. To determine roles of the viral receptor in virus infection and pathogenesis
- CD163 for PRRSV infection
- CD13 (porcine aminopeptidase N; pAPN) for PEDV infection

5. To find out the virus’s potential to modulate various signal transduction pathways

6. To develop anti-viral drugs or vaccines

7. To hunt emerging and re-emerging viruses and their killers

research_1

research_2

연구성과  
2013년 이후 대표논문

  • Jang G, Lee KK, Kim SH and Lee C. (2017)
    Prevalence, complete genome sequencing, and phylogenetic analysis of porcine deltacoronavirus in South Korea, 2014-2016.
    Transbound. Emerg. Dis., (in press)

  • Lee S and Lee C. (2017)
    Complete genome sequence of a novel S-insertion variant of porcine epidemic diarrhea virus from South Korea.
    Virus Res., (in press)

  • Lee S, Son KY, Noh YH, Lee SC, Choi HW, Yoon IJ and Lee C. (2017)
    Genetic characteristics, pathogenicity, and immunogenicity associated with cell adaptation of a virulent genotype 2b porcine epidemic diarrhea virus.
    Vet. Microbiol., 207:248-258

  • Kim Y, Jeon JH and Lee C. (2016)
    JNK and p38 mitogen-activated protein kinase pathways contribute to porcine epidemic diarrhea virus infection.
    Virus Res., 222:1-12

  • Baek PS, Choi HW, Lee S, Yoon IJ, Lee YJ, Lee DS, Lee SY and Lee C. (2016)
    Efficacy of an inactivated genotype 2b porcine epidemic diarrhea virus vaccine in neonatal piglets.
    Vet. Immunol. Immunopathol., 174:45-49

  • Lee SC, Choi HW, Nam E, Noh YH, Lee S, Lee YJ, Park GS, Shin JH, Yoon IJ, Kang SY and Lee C. (2016)
    Pathogenicity and genetic characteristics associated with cell adaptation of a virulent porcine reproductive and respiratory syndrome virus nsp2 DEL strain CA-2.
    Vet. Microbiol., 186:174-188

  • Lee YJ and Lee C. (2016)
    Ivermectin inhibits porcine reproductive and respiratory syndrome virus in cultured porcine alveolar macrophages.
    Arch. Virol., 161:257-268

  • Lee C. (2015)
    Porcine epidemic diarrhea virus: An emerging and re-emerging epizootic swine virus.
    Virol. J., 12:193

  • Lee S, Kim Y and Lee C. (2015)
    Isolation and characterization of a Korean porcine epidemic diarrhea virus strain KNU-141112.
    Virus Res., 208:215-224

  • Lee S and Lee C. (2015)
    Functional characterization and proteomic analysis of the porcine deltacoronavirus nucleocapsid protein.
    Virus Res., 208:136-145

  • Kim Y and Lee C. (2015)
    Extracellular signal-regulated kinase (ERK) activation is required for porcine epidemic diarrhea virus replication.
    Virology, 484:181-193

  • Lee DH, Jeon YS, Park CK, Kim S, Lee DS, and Lee C. (2015)
    Immunoprophylactic effect of chicken egg yolk antibody (IgY) against a recombinant S1 domain of the porcine epidemic diarrhea virus spike protein in piglets.
    Arch. Virol., 160:2197-2207

  • Kang H and Lee C. (2015)
    Sasa quelpaertensis Nakai extract suppresses porcine reproductive and respiratory syndrome virus replication and modulates virus-induced cytokine production.
    Arch. Virol., 160:1977-1988

  • Lee S, Jang G, and Lee C. (2015)
    Complete genome sequence of a porcine astrovirus from South Korea.
    Arch. Virol., 160:1819-1821

  • Lee S and Lee C. (2014)
    Complete genome characterization of Korean porcine deltacoronavirus strain KOR/KNU14-04/2014.
    Genome Announc., e01191-14

  • Lee S, Park GS, Shin JH, and Lee C. (2014)
    Full-genome sequence analysis of a variant strain of porcine epidemic diarrhea virus in South Korea.
    Genome Announc., e01116-14

  • Oh J, Lee KW, Choi HW, and Lee C. (2014)
    Immunogenicity and protective efficacy of recombinant S1 domain of the porcine epidemic diarrhea virus spike protein.
    Arch. Virol., 159:2977-2987

  • Kim Y and Lee C. (2014)
    Porcine epidemic diarrhea virus induces caspase-independent apoptosis through activation of mitochondrial apoptosis-inducing factor.
    Virology, 460-461:180-193

  • Lee S and Lee C. (2014)
    Outbreak-related porcine epidemic diarrhea virus strains similar to US strains, South Korea, 2013.
    Emerg. Infect. Dis., 20:1223-1226

  • Choi HW, Nam E, Lee YJ, Noh YH, Lee SC, Yoon IJ, Kim HS, Kang SY, Choi YK, and Lee C. (2014)
    Genomic analysis and pathogenic characteristics of Type 2 porcine reproductive and respiratory syndrome virus nsp2 deletion strains isolated in Korea.
    Vet. Microbiol., 170:232-245

  • Lee YN, Park CK, Kim SH, Lee DS, Shin JH, and Lee C. (2013)
    Characterization in vitro and in vivo of a novel porcine parainfluenza virus 5 isolate in Korea.
    Virus Res., 178:423-429

  • Lee YN and Lee C. (2013)
    Complete genome sequence of a novel porcine parainfluenza virus 5 isolate in Korea.
    Arch. Virol., 158:1765-1772

  • Kim Y and Lee C. (2013)
    Ribavirin efficiently suppresses porcine nidovirus replication.
    Virus Res., 171:44-53

  •  
    멤버사진
    확대보기  
      지도교수: 이창희

     Ph.D : 이유진
     Ph.D candidate : 이선희, 전지현, 장규환
     Undergraduate Student : 최수빈

    Contact : 053-950-7365 (Tel.) / 053-955-5522 (FAX)
    Homepage
     
    본 정보는 해당 기관에서 제공한 자료를 바탕으로 구성된 내용으로, BRIC에서 자체 생산한 정보가 아님을 밝혀드립니다.
    소개된 내용에서 중요하게 판단되는 부분은 해당 기관에 추가적으로 사실 확인 작업을 하시길 부탁드립니다.
    내용의 업데이트 또는 변경을 원하시면 관리자(member@ibric.org)에게 연락 바랍니다.
     
    목록
     
    마텍무역
    마텍무역 스폰서배너광고 안내
    이전페이지로 돌아가기 맨위로 가기
     

    BRIC 홈    BRIC 소개    회원    검색    문의/FAQ    광고    후원
    Copyright © BRIC. All rights reserved. Contact member@ibric.org

     
    에펜도르프(T:1577-4395)