[DEBUG-WINDOW 처리영역 보기]
즐겨찾기  |  뉴스레터  |  오늘의 정보 회원가입   로그인
BRIC홈 한국을 빛내는 사람들
웹진발간
스폰서배너광고 안내  배너1
전체보기 추천논문 상위피인용논문 인터뷰 그이후 한빛사통계
양현식
양현식 (Hyun-Sik Yang) 저자 이메일 보기
Harvard Medical School
 
조회 293  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Vascular risk and β‐amyloid are synergistically associated with cortical tau
열기 Authors and Affiliations

Abstract

Objective
Neuropathological studies have demonstrated that cerebrovascular disease and Alzheimer disease (AD) pathology frequently co-occur in older adults. The extent to which cerebrovascular disease influences the progression of AD pathology remains unclear. Leveraging newly available positron emission tomography (PET) imaging, we examined whether a well-validated measure of systemic vascular risk and β-amyloid (Aβ) burden have an interactive association with regional tau burden.

Methods
Vascular risk was quantified at baseline in 152 clinically normal older adults (mean age = 73.5 ± 6.1 years) with the office-based Framingham Heart Study cardiovascular disease risk algorithm (FHS-CVD). We acquired Aβ (11C-Pittsburgh compound B) and tau (18F-flortaucipir) PET imaging on the same participants. Aβ PET was performed at baseline; tau PET was acquired on average 2.98 ± 1.1 years later. Tau was measured in the entorhinal cortex (EC), an early site of tau deposition, and in the inferior temporal cortex (ITC), an early site of neocortical tau accumulation associated with AD. Linear regression models examined FHS-CVD and Aβ as interactive predictors of tau deposition, adjusting for age, sex, APOE ε4 status, and the time interval between baseline and the tau PET scan.

Results
We observed a significant interaction between FHS-CVD and Aβ burden on subsequently measured ITC tau (p < 0.001), whereby combined higher FHS-CVD and elevated Aβ burden was associated with increased tau. The interaction was not significant for EC tau (p = 0.16).

Interpretation
Elevated vascular risk may influence tau burden when coupled with high Aβ burden. These results suggest a potential link between vascular risk and tau pathology in preclinical AD. Ann Neurol 2019; 1?8 ANN NEUROL 2019;85:272-279.

논문정보
- 형식: Research article
- 게재일: 2019년 02월 (BRIC 등록일 2019-02-02)
- 연구진: 국외연구진
- 분야: Medicine, Neuroscience, Pathology
RNF20/40 의존적 eEF1BδL 모노유비퀴틴화에 의한 열충격 유전자 전사 조절[Nucleic Acids Res.]
인선아
발표: 인선아 (KAIST)
일자: 2019년 2월 22일 (금) 오후 02시 (한국시간)
언어: 한국어
참석자 접수신청하기

  댓글 0
등록
 
목록
코리아바이오믹스
관련링크
양현식 님 전체논문보기 >
관련분야 논문보기
Medicine

Neuroscience

Biochemistry

외부링크
Google (by Hyun-Sik Yang)
Pubmed (by Hyun-Sik Yang)
프리미엄 Bio일정 Bio일정 프리미엄 안내
2019 Korean Researchers’ Night in AACR 참가 신청 안내 (미국 애틀랜타)
2019 Korean Researchers’ Night in AACR 참가 신청 안내 (미국 애틀랜타)
사전접수: ~2019.02.20
날짜: 2019.03.31
장소: Atlanta Marriott Marquis
[BRIC Webinar]RNF20/40 의존적 eEF1BδL 모노유비퀴틴화에 의한 열충격 유전자 전사 조절-인선아 (KAIST)
대한골대사학회 The 7th Seoul Symposium on Bone Health & 제31차 춘계학술대회
대한골대사학회 The 7th Seoul Symposium on Bone Health & 제31차 춘계학술대회
초록접수: ~2019.02.28
사전접수: ~2019.04.01
날짜: 2019.05.30~06.01
장소: 서울드래곤시티 5층 백두룸
2019 서경배과학재단 신진과학자 연구지원 프로그램 공고
위로가기
한빛사 홈  |  한빛사FAQ  |  한빛사 문의 및 제안
 |  BRIC소개  |  이용안내  |  이용약관  |  개인정보처리방침  |  이메일무단수집거부
Copyright © BRIC. All rights reserved.  |  문의 member@ibric.org
트위터 트위터    페이스북 페이스북    RSS서비스 RSS
1550317994 0.54530200
1550317994 0.92781600
0.38251399993896 초 소요