[DEBUG-WINDOW 처리영역 보기]
즐겨찾기  |  뉴스레터  |  오늘의 정보 회원가입   로그인
BRIC홈 농수식품
시스템점검으로 인한 접속지연
스폰서배너광고 안내  배너1 배너2
전체보기 수산성과 식품성과 인터뷰
장규환
장규환 (Guehwan Jang) 저자 이메일 보기
경북대학교
 
조회 116  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Endemic outbreaks due to the re‐emergence of classical swine fever after accidental introduction of modified live LOM vaccine on Jeju Island, South Korea

GuehwanJang1, Joo-AhKim2, Won-Myoung Kang2, Hyoung-Seok Yang3, Changnam Park3, Kyongju Jeong3, Sung-Up Moon3, Choi-Kyu Park4, Young S. Lyoo5, and Changhee Lee1,*

1 Animal Virology Laboratory, School of Life Sciences, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, SouthKorea
2 Animal Health Division, Jeju Special Self-Governing Province, Jeju 63122, South Korea
3 Veterinary Research Institute, Jeju Special Self-Governing Province, Jeju 63344, SouthKorea
4 College of Veterinary  Medicine, Kyungpook  National  University, Daegu 41566, SouthKorea
5 College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea

* Corresponding author

Summary
After the unintentional vaccination of the LOM vaccine strain in 2014, classical swine fever virus (CSFV) reemerged in naive pig herds on Jeju Island, South Korea, which had been a CSF-free region with a non-vaccination policy for a decade. Since the re-emergence, endemic outbreaks of CSFV have occurred in the island, causing enormous damage to provincial pig farms. The present study reports the complete genome sequences and molecular characterization of the LOM-derived field CSFV strains responsible for the current outbreaks on Jeju Island. The emergent Jeju LOM-derived isolates shared 98.9-99.7% and 98.7-99.0% nucleotide sequence identity at the E-gene and whole-genome levels compared to the LOM vaccine strain, respectively. Genetic and phylogenetic analyses indicated that the CSFV field isolates were closest to the LOM strains, but appeared to have undergone substantial evolution. The total number of nucleotide and amino acid differences between the LOM vaccine strain and LOM-derived field isolates ranged from 111 and 28 to 148 and 42. These variations were found to be widely distributed throughout the genome and particularly accumulated in non-structural proteins, which might be associated with the potential for LOM to revert to its original low pathogenic form and subsequent horizontal transmission in Jeju swine herds. These data improve our knowledge regarding safety of the LOM vaccine and inherent risk of reversion to natural virulence in host animals.

Keywords: CSFV; Endemic outbreaks; Jeju Island; LOM-derived fieldstrains; Reversion

논문정보
- 형식: Research article
- 게재일: 2019년 01월 (BRIC 등록일 2019-01-16)
- 연구진: 국내연구진 태극기
- 분야: Veterinary_Science
  댓글 0
등록
 
목록
생화학분자생물학회
외부관련링크
Google scholar (by Guehwan Jang)
Pubmed (by Guehwan Jang)
프리미엄 Bio일정 Bio일정 프리미엄 안내
제2회 오가노이드 심포지엄 및 핸즈온워크샵 [2019 CHA Organoid Center Symposium]
제2회 오가노이드 심포지엄 및 핸즈온워크샵 [2019 CHA Organoid Center Symposium]
날짜: 2019.05.09
장소: 판교 차바이오컴플렉스 국제회의실
 
위로가기
농수식품 홈  |  농수식품 문의 및 제안
 |  BRIC소개  |  이용안내  |  이용약관  |  개인정보처리방침  |  이메일무단수집거부
Copyright © BRIC. All rights reserved.  |  문의 member@ibric.org
트위터 트위터    페이스북 페이스북   유튜브 유튜브    RSS서비스 RSS
에펜도르프코리아